A Georgetown Lombardi Comprehensive Cancer Center study reveals that the daughters of overweight dads have higher cancer risk and have altered breast tissue.
Obese male mice and normal weight female mice produce overweight female pups at birth through childhood. These female pups have delayed development of their breast tissue. Also, they have high rates of breast cancer. These findings were collected from one of the first animal studies to investigate the effect of paternal obesity on the cancer risk of the future generations.
According to the researchers, they discovered evidence that can prove how obesity can change the microRNA (miRNA) signature in both the father’s sperm and the breast tissue of the daughters. The miRNA signature is the gene expression’s epigenetic regulators. Their study suggests that miRNAs might transmit the epigenetic data from the obese fathers to their daughters.
The findings were published online in the Scientific Reports’ June 24 issue. The Georgetown Lombardi Comprehensive Cancer Center researchers reported that the miRNAs that they were able to identify, regulate insulin receptor signalling, which is connected to the changes in the body weight, and other molecular pathways that are linked to the development of cancer like the hypoxia signalling pathway.
Obesity is a type of condition where an individual has accumulated so much body fat that may cause negative effects on their health. If the body weight of an individual is at least 20% higher than it should be, he is then considered as an obese. If his Body Mass Index or BMI is between 25 and 29.9 you belong to the overweight group. If the BMI is 30 or over, you are obese.
The global incidence of obesity has increased significantly over the past decades. Technologic, economic, and lifestyle changes have made a large quantity of inexpensive, high-calorie food with minimal physical activity. People are now eating more and moving so little. There are facts that could explain the metabolic dysregulation among obese people that has been associated with various potential environmental factors like contaminants from present industry.
The rising maternal obesity rate provides a huge challenge to obstetric practice. This can lead to negative effects for both women and fetuses. The maternal risks during pregnancy include preeclampsia and diabetes. The fetus is at high risk of stillbirth and some congenital anomalies. Also, obesity during pregnancy can have an effect on the health later in life for both the mom and the child. The risks include hypertension and heart disease for women. Obesity and heart disease are the possible risks that kids will be facing in the future. Both moms and their children are at higher risk for diabetes. Many obstetrician-gynecologists are working hard to help prevent and address this epidemic.
Obesity is expected to remain foreseeable in the future. Maternal health can impact the utero environment, thus, on the development of the fetus and the child’s health later in life. Health experts are alarmed and are working double time to address this problem.
This condition seems to sometimes run in families as well as some breast cancers. Maternal obesity is said to impact both conditions in humans. This type of obesity refers to a woman during her pregnancy. ON the other hand, paternal obesity refers to the type of obesity of either mother or father during pregnancy. Both types of obesities have the significant impact on the metabolism and offspring development. A woman who is overweight, while pregnant can produce bigger babies, who may have a higher risk of breast cancer later in life.
In the past, the focus has been more on the maternal side. Only a few, if any research has examined the impact of the father’s overweight and obesity on the cancer risk of his offspring.
The Georgetown Lombardi Comprehensive Cancer Center study provides proof that, in animals, the body weight of a father at the period of conception influences both their daughter’s body weight both at birth and in the childhood and their breast cancer risk in the future. This is according to Dr. Sonia de Assis, is the lead investigator of the study. She is also an assistant professor at Georgetown Lombardi.
Of course, their study was performed in mice, but it recapitulates latest findings in humans, which illustrate that obese men have important epigenetic alterations in their sperm compared to healthy and lean men.
Their animal study says that those epigenetic alterations in sperm may have impacts for the next generation’s cancer risk.
Dr. de Assis mentions that their next step in the research is to investigate if the same associations can be connected between human dads who are overweight at the risk of breast cancer among their daughters. She added that until they know about this connection with men, they would stick to what they identify is a great piece of advice. Both men and women must keep on trying their best to have a well-balanced diet, sustain a healthy body weight, and live a healthy lifestyle.
These practices will not only benefit everyone, but it could also possibly lead to much happier and healthier kids, whether people plan on getting pregnant in the future or not. Prevention is the key to success when it comes to routines and health and is very hard to break once those strong habits are already formed.
The Georgetown Lombardi Comprehensive Cancer Center team plans to conduct more studies to get more direct answers about the human consequences of dads being overweight during the conception on their unborn kids.
It is possible that they may study and test other animals and gather a better concept as to how these alterations happen and if there are other ways that technology can carry out changing the potential results. There might be other genes that lower the risk for cancer, even if the who must have a bigger risk.
It is very crucial to take steps to deal with obesity because it can cause obvious physical changes. Furthermore, it leads to a number of severe and probably serious conditions like coronary heart disease, type 2 diabetes, stroke, and breast cancer.
In addition, obesity can affect your quality of life and cause to psychological problems like low self-esteem and depression.